ULM professors garner another patent - KNOE 8 News; KNOE-TV; KNOE.com |

ULM professors garner another patent

Posted: Updated: Oct 4, 2012 01:55 PM

MONROE, La., (KNOE 8 News) - The United States Patent & Trademark Office has awarded professors at the University of Louisiana at Monroe's College of Pharmacy another patent for potentially life-saving anticancer research—(US 8,268,786 B2). This is the fourth patent awarded to the college.

Dr. Khalid El Sayed, associate professor of pharmacy, and Dr. Paul W. Sylvester, Pfizer endowed professor of pharmacology and director of graduate studies and research at ULM, have been awarded the patent for their cancer research. Dr. Amal Khalil Kaddoumi, assistant professor in pharmacy, and Dr. Sami Nazzal, associate professor of pharmacy, also collaborated on the research.

The patent is titled "Anti-cancer tocotrienol analogues and associated methods." Tocotrienol is a rare, but natural form of Vitamin E. This patent stems from research collaboration between ULM College of Pharmacy faculty and First Tech International Limited in Wanchai, Hong Kong.

"The patent is the first reward for several years of collaborative research activity," said El Sayed. "The palm oil research group led by Dr. Sylvester is a perfect example of integrating unique strengths and diverse, distinguished expertise in the ULM College of Pharmacy." 

The prospective uses of these newly discovered anticancer agents are significant within the field of cancer research.

"The patent is for new and potent anticancer agents that were developed by creating carbamate ester analogues of natural tocotrienols—a natural, but rare form of vitamin E," said Sylvester. "Specifically, these compounds show significant potential for use in the treatment of breast cancer."

According to Sylvester, the anticancer activity of tocotrienols is well established, but this activity is reduced in the body due to poor absorption by the intestine and rapid metabolism in the body. 

"The newly awarded patent discloses the invention of novel tocotrienol derivatives with anti-cancer effects, methods of making such compounds, and methods of cancer treatment and prevention involving those compounds that are useful in the fields of cancer treatment, prevention, and research," continued Sylvester.

Because of this, studies were conducted to develop derivatives by making subtle changes in the natural molecular structure of the vitamin E compounds, resulting in novel tocotrienol-carbamate derivatives that display increased chemical and metabolic stability, increased water solubility, and increased anticancer potency. 

El Sayed said the team is acting as an effective small company. Sylvester discovered the potent activity of the original natural products and understood their mechanism of action, and Dr. Kaddoumi discovered the mechanism of the compound's absorption in the intestine.

The College of Pharmacy—the only state-supported pharmacy program in Louisiana—continues to make advancements in cancer research through an effort to combine the expertise of various faculty, creating greater results.

  • Most Popular StoriesMost Popular StoriesMore>>

  • Pipe beating leads to arrest

    Pipe beating leads to arrest

    Thursday, August 28 2014 5:02 PM EDT2014-08-28 21:02:44 GMT
    UNION PARISH, La. (KNOE 8 News UPSO) - A Junction City man has been booked into the Union Parish Detention Center accused of striking another man in the head with a pipe.
    UNION PARISH, La. (KNOE 8 News UPSO) - A Junction City man has been booked into the Union Parish Detention Center accused of striking another man in the head with a pipe.
  • KNOE tailgates with a ULM Grove legend

    KNOE tailgates with a ULM Grove legend

    Thursday, August 28 2014 5:17 PM EDT2014-08-28 21:17:41 GMT
    MONROE, La. (KNOE 8 News)- Buddy Embanato is a familiar face in the Grove during football season.
    MONROE, La. (KNOE 8 News)- Buddy Embanato is a familiar face in the Grove during football season.
  • Local Red Cross Chapter slashed in cutbacks

    Local Red Cross Chapter slashed in cutbacks

    Thursday, August 28 2014 2:22 PM EDT2014-08-28 18:22:44 GMT
    MONROE, La. (KNOE 8 News) - Big changes at the American Red Cross on a national level are having an effect on local staffing. As part of restructuring, the Northeast Louisiana Chapter based in Monroe is loosing its executive director and three other full time employees.
    MONROE, La. (KNOE 8 News) - Big changes at the American Red Cross on a national level are having an effect on local staffing. As part of restructuring, the Northeast Louisiana Chapter based in Monroe is loosing its executive director and three other full time employees.
  • Teacher accused of having sex with 2 students

    Teacher accused of having sex with 2 students

    Thursday, August 28 2014 9:53 AM EDT2014-08-28 13:53:04 GMT
    BATON ROUGE, La. (AP) - Riverdale Christian Academy administrators have fired English teacher Ashley Dowden following her confession to deputies that she had sex with a 16-year-old student.
    BATON ROUGE, La. (AP) - Riverdale Christian Academy administrators have fired English teacher Ashley Dowden following her confession to deputies that she had sex with a 16-year-old student.
  • Stabbing on Church Street

    Stabbing on Church Street

    Friday, August 29 2014 9:14 AM EDT2014-08-29 13:14:01 GMT
    MONROE, La. (KNOE 8 NEWS) - Multiple stab wounds sends one to the hospital.
    MONROE, La. (KNOE 8 NEWS) - Multiple stab wounds sends one to the hospital.
  • Gun company cuts ties with reality TV star

    Gun company cuts ties with reality TV star

    Thursday, August 28 2014 1:59 PM EDT2014-08-28 17:59:12 GMT
    BATON ROUGE, La. (AP) - A firearms company affiliated with reality TV star Will Hayden is distancing itself from him after his arrest on rape charges. In a statement on its website, Red Jacket Firearms LLC says it has legally separated from Hayden.
    BATON ROUGE, La. (AP) - A firearms company affiliated with reality TV star Will Hayden is distancing itself from him after his arrest on rape charges. In a statement on its website, Red Jacket Firearms LLC says it has legally separated from Hayden.
  • Shooting on Lowery Street

    Shooting on Lowery Street

    Friday, August 29 2014 9:08 AM EDT2014-08-29 13:08:38 GMT
    MONROE, La. (KNOE 8 NEWS) - Shooting on Lowery Street sends one person to the hospital.
    MONROE, La. (KNOE 8 NEWS) - Shooting on Lowery Street sends one person to the hospital.
  • Fixing the roads... One pothole at a time

    Fixing the roads... One pothole at a time

    Thursday, August 28 2014 9:21 PM EDT2014-08-29 01:21:38 GMT
    WINNSBORO, La (KNOE 8 NEWS) -- Eighteen roads in Franklin Parish are about to get a face lift, thanks to the Ad Valorem tax and extra state funding.
    WINNSBORO, La (KNOE 8 NEWS) -- Eighteen roads in Franklin Parish are about to get a face lift, thanks to the Ad Valorem tax and extra state funding.
Powered by WorldNow
All content © Copyright 2000 - 2014 WorldNow and KNOE. All Rights Reserved.
For more information on this site, please read our Privacy Policy and Terms of Service.